Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | CRBN | Q96SW2 | 15/20 | 0.45 |
| ▸ | DDB1 | Q16531 | 14/20 | 0.45 |
| ▸ | GSPT1 | P15170 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.36 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26266604 | 0.88 | CRBN (0.45) | POLBCRBNDDB1GSPT1KCNH2 | |
| SCHEMBL26266552 | 0.87 | CRBN (0.46) | POLBCRBNDDB1GSPT1ALDH1A1 | |
| SCHEMBL24754196 | 0.85 | CRBN (0.52) | POLBCRBNDDB1GSPT1ALDH1A1 | |
| SCHEMBL26259198 | 0.81 | CRBN (0.60) | CRBNDDB1GSPT1HRH3 | |
| SCHEMBL24530620 | 0.76 | CRBN (0.55) | CRBNDDB1HRH3PDCD1CD274 | |
| SCHEMBL24530827 | 0.75 | CRBN (0.45) | CRBNDDB1GSPT1RAB9A | |
| SCHEMBL25452713 | 0.75 | POLB (0.58) | POLBCRBNDDB1KCNH2HRH3 | |
| SCHEMBL26750538 | 0.75 | CRBN (0.54) | POLBCRBNDDB1ALDH1A1RAB9A | |
| SCHEMBL31355988 | 0.74 | CRBN (0.42) | POLBCRBNDDB1GSPT1 | |
| SCHEMBL24754213 | 0.73 | DDB1 (0.48) | CRBNDDB1GSPT1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023220640-A1 | CDK PROTEIN DEGRADERS, PHARMACEUTICAL COMPOSITIONS, AND THERAPEUTIC APPLICATIONS | BIOTHERYX, INC. (US) | 2023-11-16 | — | — | WO | disclosed |
| WO-2023023531-A1 | ESTROGEN RECEPTOR DEGRADERS, PHARMACEUTICAL COMPOSITIONS, AND THERAPEUTIC APPLICATIONS | BIOTHERYX, INC. (US) | 2023-02-23 | — | — | WO | disclosed |
| WO-2022132603-A1 | PDE4 DEGRADERS, PHARMACEUTICAL COMPOSITIONS, AND THERAPEUTIC APPLICATIONS | BIOTHERYX, INC. (US) | 2022-06-23 | — | — | WO | disclosed |