Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.36 |
| ▸ | CREBBP | Q92793 | 13/20 | 0.35 |
| ▸ | EP300 | Q09472 | 3/20 | 0.35 |
| ▸ | BRD4 | O60885 | 10/20 | 0.35 |
| ▸ | CDK4 | P11802 | 2/20 | 0.35 |
| ▸ | CCND1 | P24385 | 2/20 | 0.35 |
| ▸ | CCND2 | P30279 | 2/20 | 0.35 |
| ▸ | CCND3 | P30281 | 2/20 | 0.35 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.32 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2447366 | 0.94 | SYK (0.40) | SYKCREBBPEP300BRD4CDK4 | |
| SCHEMBL2447045 | 0.91 | CREBBP (0.41) | SYKCREBBPEP300BRD4CDK4 | |
| SCHEMBL2477781 | 0.88 | SYK (0.40) | SYKCREBBPBRD4CDK4CCND1 | |
| SCHEMBL2448058 | 0.85 | GPBAR1 (0.37) | SYKCREBBPEP300BRD4GPBAR1 | |
| SCHEMBL8904900 | 0.85 | MAPT (0.44) | SYKCDK4CCND1CCND2CCND3 | |
| SCHEMBL2451543 | 0.83 | SYK (0.41) | SYKCREBBPBRD4CDK4CCND1 | |
| SCHEMBL2479399 | 0.82 | SYK (0.37) | SYKBRD4CDK4CCND1CCND2 | |
| SCHEMBL8905497 | 0.82 | MAPT (0.46) | CDK4CCND1CCND2CCND3GPBAR1 | |
| SCHEMBL2447812 | 0.81 | LRRK2 (0.40) | SYKCREBBPEP300BRD4CDK4 | |
| SCHEMBL2480088 | 0.81 | SYK (0.37) | SYKCDK4CCND1CCND2CCND3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2367826-A1 | MODULATORS OF AMYLOID BETA. | AstraZeneca AB (SE) | 2011-09-28 | — | — | EP | disclosed |
| WO-2010053438-A1 | MODULATORS OF AMYLOID BETA. | ASTRAZENECA AB (SE) | 2010-05-14 | — | — | WO | disclosed |