Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SGK1 | O00141 | 2/20 | 0.31 |
| ▸ | RORC | P51449 | 3/20 | 0.31 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.31 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | METAP2 | P50579 | 1/20 | 0.31 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.30 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.30 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26598099 | 0.85 | CYP1A2 (0.36) | CYP1A2 | |
| SCHEMBL23043112 | 0.84 | SGK1 (0.33) | SGK1CNR2 | |
| SCHEMBL24536822 | 0.79 | KRAS (0.36) | — | |
| SCHEMBL29679962 | 0.79 | KRAS (0.36) | — | |
| SCHEMBL31691592 | 0.77 | KRAS (0.47) | — | |
| SCHEMBL30922767 | 0.77 | KRAS (0.47) | — | |
| SCHEMBL26629565 | 0.77 | MEN1 (0.44) | SCN9A | |
| SCHEMBL23043428 | 0.76 | KRAS (0.48) | — | |
| SCHEMBL30706977 | 0.75 | KRAS (0.35) | — | |
| SCHEMBL24536776 | 0.75 | KRAS (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022132200-A1 | AZAQUINAZOLINE PAN-KRAS INHIBITORS | Mirati Therapeutics, Inc. (US) | 2022-06-23 | — | — | WO | disclosed |