Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.46 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | PREP | P48147 | 2/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.39 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16925538 | 0.98 | HPGD (0.50) | HPGDESR2NR1H2USP2SMN1; SMN2 | |
| SCHEMBL893656 | 0.95 | ESR2 (0.47) | HPGDESR2NR1H2USP2SMN1; SMN2 | |
| SCHEMBL1063509 | 0.88 | ESR2 (0.52) | HPGDESR2NR1H2USP2SMN1; SMN2 | |
| SCHEMBL21876055 | 0.84 | USP2 (0.50) | HPGDESR2NR1H2USP2SMN1; SMN2 | |
| SCHEMBL1336913 | 0.82 | HPGD (0.49) | HPGDESR2NR1H2USP2SMN1; SMN2 | |
| SCHEMBL689236 | 0.82 | HPGD (0.49) | HPGDESR2NR1H2USP2SMN1; SMN2 | |
| SCHEMBL10053997 | 0.82 | HPGD (0.47) | HPGDNR1H2USP2SMN1; SMN2MEN1 | |
| SCHEMBL1488353 | 0.81 | USP2 (0.48) | HPGDESR2NR1H2USP2SMN1; SMN2 | |
| SCHEMBL30707004 | 0.81 | HPGD (0.51) | HPGDESR2NR1H2USP2SMN1; SMN2 | |
| SCHEMBL18084854 | 0.79 | USP2 (0.50) | HPGDESR2NR1H2USP2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4262807-A1 | AZAQUINAZOLINE PAN-KRAS INHIBITORS | Mirati Therapeutics, Inc. (US) | 2023-10-25 | — | — | EP | disclosed |
| WO-2022132200-A1 | AZAQUINAZOLINE PAN-KRAS INHIBITORS | Mirati Therapeutics, Inc. (US) | 2022-06-23 | — | — | WO | disclosed |
| WO-2022132200-A1 | AZAQUINAZOLINE PAN-KRAS INHIBITORS | Mirati Therapeutics, Inc. (US) | 2022-06-23 | — | — | WO | disclosed |