SCHEMBL2454634

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

	Compound	similarity	top predicted	shared targets
	SCHEMBL2457095	0.90	KDR (0.57)	ABL1BCRKDRBRAFKIT
	SCHEMBL2450792	0.89	KDR (0.54)	ABL1KDRBRAFKITPDGFRA
	SCHEMBL2454644	0.86	KDR (0.51)	KDRBRAFKITPDGFRATEK
	SCHEMBL12334319	0.85	DYRK1A (0.54)	ABL1KDRBRAFKITPDGFRA
	SCHEMBL2450325	0.85	KDR (0.49)	KDRBRAFKITPDGFRATEK
	SCHEMBL2453229	0.84	KDR (0.51)	ABL1KDRBRAFKITPDGFRA
	SCHEMBL2857403	0.81	BRAF (0.51)	ABL1KDRBRAFKITPDGFRA
	SCHEMBL2458469	0.78	KDR (0.57)	KDRBRAFKITPDGFRATEK
	SCHEMBL2455663	0.77	KDR (0.58)	KDRBRAFKITPDGFRATEK
	SCHEMBL2455490	0.77	KDR (0.51)	ABL1KDRBRAFKITPDGFRA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.