Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1B | Q00975 | 13/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | TRPV4 | Q9HBA0 | 3/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.34 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2844230 | 1.00 | CACNA1B (0.53) | CACNA1BGAATRPV4EPHX2HSD11B1 | |
| SCHEMBL66499 | 0.94 | CACNA1B (0.49) | CACNA1BGAATRPV4EPHX2HSD11B1 | |
| SCHEMBL2457600 | 0.92 | CACNA1B (0.54) | CACNA1BGAATRPV4HSD11B1 | |
| SCHEMBL2851897 | 0.92 | CACNA1B (0.54) | CACNA1BGAATRPV4HSD11B1 | |
| SCHEMBL66498 | 0.91 | CACNA1B (0.50) | CACNA1BGAATRPV4EPHX2HSD11B1 | |
| SCHEMBL2849997 | 0.90 | CACNA1B (0.53) | CACNA1BGAATRPV4HSD11B1 | |
| SCHEMBL2846870 | 0.89 | CACNA1B (0.56) | CACNA1BGAATRPV4HSD11B1 | |
| SCHEMBL66376 | 0.88 | CACNA1B (0.64) | CACNA1BGAATRPV4EPHX2HSD11B1 | |
| SCHEMBL67409 | 0.87 | CACNA1B (0.67) | CACNA1BGAATRPV4EPHX2 | |
| SCHEMBL66321 | 0.86 | CACNA1B (0.50) | CACNA1BGAATRPV4HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2367790-A2 | SUBSTITUTED OCTAHYDROCYCLOPENTA(C)PYRROL-4-AMINES AS CALCIUM CHANNEL BLOCKERS | Abbott Laboratories (US) | 2011-09-28 | — | — | EP | claimed |
| WO-2010062927-A2 | NOVEL SUBSTITUTED OCTAHYDROCYCLOPENTA(C)PYRROL-4-AMINES AS CALCIUM CHANNEL BLOCKERS | ABBOTT LABORATORIES (US) | 2010-06-03 | — | — | WO | claimed |
| WO-2011149995-A1 | NOVEL SUBSTITUTED OCTAHYDROCYCLOPENTA [C]PYRROL-4-AMINES AS CALCIUM CHANNEL BLOCKERS | ABBOTT LABORATORIES (US) | 2011-12-01 | — | — | WO | disclosed |
| EP-2367790-A2 | SUBSTITUTED OCTAHYDROCYCLOPENTA(C)PYRROL-4-AMINES AS CALCIUM CHANNEL BLOCKERS | Abbott Laboratories (US) | 2011-09-28 | — | — | EP | disclosed |
| WO-2010062927-A2 | NOVEL SUBSTITUTED OCTAHYDROCYCLOPENTA(C)PYRROL-4-AMINES AS CALCIUM CHANNEL BLOCKERS | ABBOTT LABORATORIES (US) | 2010-06-03 | — | — | WO | disclosed |