Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | GRIN2D | O15399 | 4/20 | 0.41 |
| ▸ | GRIN3B | O60391 | 4/20 | 0.41 |
| ▸ | GRIN1 | Q05586 | 4/20 | 0.41 |
| ▸ | GRIN2A | Q12879 | 4/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.41 |
| ▸ | GRIN2C | Q14957 | 4/20 | 0.41 |
| ▸ | GRIN3A | Q8TCU5 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | THPO | P40225 | 1/20 | 0.38 |
| ▸ | MTOR | P42345 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | HBB | P68871 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15478582 | 0.77 | HSD17B10 (0.56) | HSD17B10KDM4EHPGDGAAGRIN2D | |
| SCHEMBL24551105 | 0.76 | GRIN2D (0.43) | HSD17B10KDM4EHPGDGAAGRIN2D | |
| SCHEMBL24550342 | 0.74 | PDE3B (0.38) | HSD17B10KDM4EHPGDGAAGRIN2D | |
| SCHEMBL9846132 | 0.71 | PDE3B (0.53) | HSD17B10KDM4EHPGDGAAGRIN2D | |
| SCHEMBL27271864 | 0.71 | HSD17B10 (0.50) | HSD17B10KDM4EHPGDGAAGRIN2D | |
| SCHEMBL12946182 | 0.71 | HSD17B10 (0.50) | HSD17B10KDM4EHPGDGAAGRIN2D | |
| SCHEMBL24550679 | 0.71 | GAA (0.38) | HSD17B10KDM4EHPGDGAAALDH1A1 | |
| SCHEMBL24968371 | 0.71 | HPGD (0.46) | HSD17B10KDM4EHPGDGAAGRIN2D | |
| SCHEMBL215086 | 0.70 | HSD17B10 (0.48) | HSD17B10KDM4EHPGDGAAGRIN2D | |
| SCHEMBL20844173 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022129281-A1 | NITROGEN CONTAINING 2,3-DIHYDROQUINAZOLINONE COMPOUNDS AS NAV1.8 INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2022-06-23 | — | — | WO | disclosed |