Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 12/20 | 0.44 |
| ▸ | BRD9 | Q9H8M2 | 3/20 | 0.43 |
| ▸ | BRD7 | Q9NPI1 | 3/20 | 0.43 |
| ▸ | TAF1 | P21675 | 2/20 | 0.43 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.43 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.43 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.43 |
| ▸ | CECR2 | Q9BXF3 | 2/20 | 0.43 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.43 |
| ▸ | BPTF | Q12830 | 1/20 | 0.43 |
| ▸ | TAF1L | Q8IZX4 | 1/20 | 0.43 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.43 |
| ▸ | ATAD2B | Q9ULI0 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | ACVR2B | Q13705 | 1/20 | 0.43 |
| ▸ | BRD8 | Q9H0E9 | 1/20 | 0.43 |
| ▸ | KAT2B | Q92831 | 2/20 | 0.41 |
| ▸ | NFATC1 | O95644 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24556359 | 0.94 | BRD4 (0.43) | BRD4BRD9BRD7TAF1TGFBR1 | |
| SCHEMBL16019431 | 0.78 | DYRK1A (0.56) | TGFBR1NFATC1GSK3BDYRK1AAURKB | |
| SCHEMBL24654861 | 0.78 | DYRK1A (0.44) | TGFBR1CYP2D6NFATC1GSK3BDYRK1A | |
| SCHEMBL23134731 | 0.78 | BRD4 (0.51) | BRD4BRD9BRD7TAF1TGFBR1 | |
| SCHEMBL12563121 | 0.78 | BRD4 (0.55) | BRD4BRD9BRD7TDP1 | |
| SCHEMBL22306886 | 0.77 | BRD4 (0.46) | BRD4BRD9BRD7TAF1TGFBR1 | |
| SCHEMBL16651223 | 0.77 | BRD4 (0.46) | BRD4BRD9BRD7TAF1TGFBR1 | |
| SCHEMBL23783324 | 0.77 | HASPIN (0.49) | BRD4BRD9BRD7TAF1TGFBR1 | |
| SCHEMBL24556448 | 0.75 | BRD4 (0.46) | BRD4BRD9BRD7TAF1TGFBR1 | |
| SCHEMBL19869619 | 0.74 | BRD4 (0.44) | BRD4BRD9BRD7TAF1TGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3265453-B1 | NEW PYRIDINONES AND ISOQUINOLINONES AS INHIBITORS OF THE BROMODOMAIN BRD9 | BOEHRINGER INGELHEIM INT (DE) | 2022-06-29 | — | — | EP | disclosed |