Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 5/20 | 0.47 |
| ▸ | KDM4A | O75164 | 1/20 | 0.47 |
| ▸ | KDM4B | O94953 | 1/20 | 0.47 |
| ▸ | KDM5C | P41229 | 1/20 | 0.47 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.47 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.47 |
| ▸ | PARP1 | P09874 | 5/20 | 0.42 |
| ▸ | PIM1 | P11309 | 2/20 | 0.41 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.41 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.38 |
| ▸ | CSNK2A1 | P68400 | 3/20 | 0.38 |
| ▸ | GSK3B | P49841 | 2/20 | 0.38 |
| ▸ | CDK2 | P24941 | 2/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30596070 | 0.78 | HASPIN (0.49) | KDM4CKDM4AKDM4BKDM5CKDM5B | |
| SCHEMBL17163962 | 0.78 | KDM4C (0.47) | KDM4CKDM4AKDM4BKDM5CKDM5B | |
| SCHEMBL22305924 | 0.78 | KDM5C (0.47) | KDM4CKDM4AKDM4BKDM5CKDM5B | |
| SCHEMBL16139620 | 0.78 | KDM5C (0.47) | KDM4CKDM4AKDM4BKDM5CKDM5B | |
| SCHEMBL245345 | 0.78 | KDM4C (0.47) | KDM4CKDM4AKDM4BKDM5CKDM5B | |
| SCHEMBL17164016 | 0.78 | GSK3B (0.48) | KDM4CKDM4AKDM4BKDM5CKDM5B | |
| SCHEMBL245965 | 0.77 | KDM4A (0.44) | KDM4CKDM4AKDM4BKDM5CKDM5B | |
| SCHEMBL25003259 | 0.77 | KDM4C (0.44) | KDM4CKDM4AKDM4BKDM5CKDM5B | |
| Bromide SCHEMBL14969315 | 0.76 | KDM5C (0.46) | KDM4CKDM4AKDM4BKDM5CKDM5B | |
| SCHEMBL2619228 | 0.75 | DYRK1A (0.56) | PIM1PIM3PIM2DYRK1AGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3265453-B1 | NEW PYRIDINONES AND ISOQUINOLINONES AS INHIBITORS OF THE BROMODOMAIN BRD9 | BOEHRINGER INGELHEIM INT (DE) | 2022-06-29 | — | — | EP | disclosed |