Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 18/20 | 0.52 |
| ▸ | WDR77 | Q9BQA1 | 9/20 | 0.52 |
| ▸ | METTL3 | Q86U44 | 9/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24380378 | 0.91 | PRMT5 (0.51) | PRMT5WDR77METTL3 | |
| SCHEMBL26549733 | 0.90 | PRMT5 (0.57) | PRMT5WDR77METTL3 | |
| SCHEMBL18571831 | 0.90 | PRMT5 (0.57) | PRMT5WDR77METTL3 | |
| SCHEMBL22002116 | 0.84 | PRMT5 (0.42) | PRMT5WDR77METTL3 | |
| SCHEMBL18571832 | 0.81 | PRMT5 (0.76) | PRMT5WDR77METTL3 | |
| SCHEMBL18571709 | 0.81 | PRMT5 (0.47) | PRMT5WDR77METTL3 | |
| SCHEMBL22002280 | 0.81 | PRMT5 (0.55) | PRMT5WDR77METTL3 | |
| SCHEMBL18572233 | 0.81 | PRMT5 (0.53) | PRMT5WDR77METTL3 | |
| SCHEMBL18572318 | 0.81 | PRMT5 (0.54) | PRMT5WDR77METTL3 | |
| SCHEMBL18572298 | 0.81 | PRMT5 (0.58) | PRMT5WDR77METTL3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220205026-A1 | Use of Biomarkers in Identifying Cancer Patients That Will Be Responsive to Treatment With a PRMT5 Inhibitor | JANSSEN PHARMACEUTICA NV (BE) | 2022-06-30 | — | — | US | disclosed |