Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 7/20 | 0.56 |
| ▸ | PIK3CA | P42336 | 19/20 | 0.44 |
| ▸ | PIK3CB | P42338 | 6/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.38 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL247039 | 0.91 | PIK3CD (0.63) | PIK3CDPIK3CAPIK3CBPIK3CGPIK3R1 | |
| SCHEMBL3410299 | 0.88 | PIK3CD (0.59) | PIK3CDPIK3CAPIK3CBPIK3CGPIK3R1 | |
| SCHEMBL246264 | 0.88 | PIK3CD (0.57) | PIK3CDPIK3CAPIK3CBPIK3CGPIK3R1 | |
| SCHEMBL246090 | 0.88 | PIK3CD (0.59) | PIK3CDPIK3CAPIK3CBPIK3CGPIK3R1 | |
| SCHEMBL14840097 | 0.88 | PIK3CD (0.58) | PIK3CDPIK3CAPIK3CBPIK3CGPIK3R1 | |
| SCHEMBL247954 | 0.88 | PIK3CD (0.60) | PIK3CDPIK3CAPIK3CBPIK3CGPIK3R1 | |
| SCHEMBL245772 | 0.88 | PIK3CD (0.58) | PIK3CDPIK3CAPIK3CBPIK3CGPIK3R1 | |
| SCHEMBL14840096 | 0.87 | PIK3CD (0.60) | PIK3CDPIK3CAPIK3CBPIK3CGPIK3R1 | |
| SCHEMBL247580 | 0.86 | PIK3CD (0.57) | PIK3CDPIK3CAPIK3CBPIK3CGPIK3R1 | |
| SCHEMBL247705 | 0.85 | PIK3CD (0.55) | PIK3CDPIK3CAPIK3CBPIK3CGPIK3R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2588471-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS INHIBITORS OF PI3K ACTIVITY | Amgen Inc. (US) | 2013-05-08 | — | — | EP | disclosed |
| WO-2012003283-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS INHIBITORS OF PI3K ACTIVITY | AMGEN INC. (US) | 2012-01-05 | — | — | WO | disclosed |