Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | TTK | P33981 | 1/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.42 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 10/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15574103 | 0.85 | AURKA (0.45) | AURKATTKAURKBINCENPBRD4 | |
| SCHEMBL4049112 | 0.79 | AURKA (0.46) | AURKATTKAURKBINCENPBRD4 | |
| SCHEMBL24566178 | 0.71 | — | — | |
| SCHEMBL16794683 | 0.71 | AURKA (0.49) | AURKATTKAURKBINCENPBRD4 | |
| SCHEMBL28223511 | 0.70 | AURKA (0.52) | AURKATTKAURKBINCENPBRD4 | |
| SCHEMBL15006071 | 0.69 | AURKA (0.50) | AURKATTKAURKBINCENPBRD4 | |
| SCHEMBL14993737 | 0.67 | AURKA (0.49) | AURKATTKAURKBINCENPBRD4 | |
| SCHEMBL106685 | 0.67 | AURKA (0.49) | AURKATTKAURKBINCENPBRD4 | |
| SCHEMBL13456010 | 0.67 | AURKA (0.49) | AURKATTKAURKBINCENPBRD4 | |
| SCHEMBL22927054 | 0.66 | PTPN5 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022140527-A1 | 6-HETEROARYLOXY BENZIMIDAZOLES AND AZABENZIMIDAZOLES AS JAK2 INHIBITORS | AJAX THERAPEUTICS, INC. (US) | 2022-06-30 | — | — | WO | disclosed |