Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.61 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
| ▸ | GPR183 | P32249 | 2/20 | 0.38 |
| ▸ | FAAH | O00519 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.35 |
| ▸ | ACHE | P22303 | 2/20 | 0.35 |
| ▸ | CNR2 | P34972 | 4/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24566101 | 0.92 | NR1H2 (0.59) | NR1H2POLBGLAGAATSHR | |
| SCHEMBL20912724 | 0.92 | NR1H2 (0.68) | NR1H2POLBGLAGAATSHR | |
| SCHEMBL29958937 | 0.92 | NR1H2 (0.68) | NR1H2POLBGLAGAATSHR | |
| SCHEMBL29958764 | 0.89 | NR1H2 (0.63) | NR1H2POLBGLAGAATSHR | |
| SCHEMBL4933173 | 0.80 | NR1H2 (0.76) | NR1H2POLBGLAGAATSHR | |
| SCHEMBL545052 | 0.80 | NR1H2 (0.76) | NR1H2POLBGLAGAATSHR | |
| SCHEMBL27088111 | 0.80 | NR1H2 (0.67) | NR1H2POLBGLAGAATSHR | |
| SCHEMBL29175928 | 0.79 | NR1H2 (0.74) | NR1H2POLBGLAGAATSHR | |
| SCHEMBL29998843 | 0.79 | NR1H2 (0.74) | NR1H2POLBGLAGAATSHR | |
| SCHEMBL3166705 | 0.79 | NR1H2 (0.74) | NR1H2POLBGLAGAATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022140527-A1 | 6-HETEROARYLOXY BENZIMIDAZOLES AND AZABENZIMIDAZOLES AS JAK2 INHIBITORS | AJAX THERAPEUTICS, INC. (US) | 2022-06-30 | — | — | WO | disclosed |