Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHB3 | P54753 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | LGMN | Q99538 | 2/20 | 0.42 |
| ▸ | SMPD3 | Q9NY59 | 2/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL33913 | 0.82 | SMPD3 (0.55) | EPHB3MAPTALDH1A1RAB9ANPC1 | |
| SCHEMBL24567286 | 0.82 | EPHB3 (0.53) | EPHB3MAPTALDH1A1RAB9ANPC1 | |
| SCHEMBL24567287 | 0.82 | EPHB3 (0.53) | EPHB3MAPTALDH1A1RAB9ANPC1 | |
| SCHEMBL17437883 | 0.78 | EPHB3 (0.63) | EPHB3MAPTALDH1A1RAB9ANPC1 | |
| SCHEMBL17454455 | 0.77 | EPHB3 (0.62) | EPHB3MAPTALDH1A1L3MBTL1BRD9 | |
| SCHEMBL27431439 | 0.77 | EPHB3 (0.62) | EPHB3SMPD3BRD9BAZ2B | |
| SCHEMBL17452618 | 0.74 | EPHB3 (0.59) | EPHB3MAPTALDH1A1L3MBTL1BRD9 | |
| SCHEMBL24567289 | 0.72 | CYP3A4 (0.48) | EPHB3ALDH1A1MEN1KMT2ATSHR | |
| SCHEMBL24567288 | 0.72 | HTT (0.51) | EPHB3MAPTALDH1A1RAB9ANPC1 | |
| SCHEMBL31469893 | 0.72 | EPHB3 (0.56) | EPHB3MAPTALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022140527-A1 | 6-HETEROARYLOXY BENZIMIDAZOLES AND AZABENZIMIDAZOLES AS JAK2 INHIBITORS | AJAX THERAPEUTICS, INC. (US) | 2022-06-30 | — | — | WO | disclosed |