Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 1/20 | 0.38 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | KDM5A | P29375 | 1/20 | 0.33 |
| ▸ | APP | P05067 | 1/20 | 0.33 |
| ▸ | PLK4 | O00444 | 1/20 | 0.32 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.32 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.32 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.32 |
| ▸ | PAK4 | O96013 | 1/20 | 0.32 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.32 |
| ▸ | INSR | P06213 | 1/20 | 0.32 |
| ▸ | CDK1 | P06493 | 1/20 | 0.32 |
| ▸ | FES | P07332 | 1/20 | 0.32 |
| ▸ | ROS1 | P08922 | 1/20 | 0.32 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.32 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.32 |
| ▸ | FER | P16591 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23970943 | 0.81 | CDK8 (0.41) | AXLNUDT1BRD4KDM5APLK4 | |
| SCHEMBL24087398 | 0.76 | BRD4 (0.36) | AXLNUDT1BRD4 | |
| SCHEMBL27732331 | 0.76 | AXL (0.41) | AXLNUDT1BRD4KDM5AAPP | |
| SCHEMBL1855794 | 0.74 | MGAM (0.46) | AXLNUDT1BRD4KDM5ATNKS | |
| SCHEMBL19539184 | 0.74 | CDK8 (0.43) | AXLNUDT1BRD4KDM5ACDK8 | |
| SCHEMBL1161415 | 0.74 | CDK8 (0.43) | BRD4CDK8 | |
| SCHEMBL19463620 | 0.73 | PIM1 (0.43) | AXLNUDT1KDM5ACDK8CDK7 | |
| SCHEMBL21188434 | 0.73 | F2 (0.41) | AXLNUDT1BRD4KDM5AAPP | |
| SCHEMBL21178504 | 0.73 | AXL (0.38) | AXLNUDT1BRD4KDM5AAPP | |
| SCHEMBL21178857 | 0.72 | AXL (0.37) | AXLNUDT1BRD4KDM5AAPP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022140390-A1 | INHIBITORS OF PEPTIDYLARGININE DEIMINASES | GILEAD SCIENCES, INC. (US) | 2022-06-30 | — | — | WO | disclosed |