Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 4/20 | 0.47 |
| ▸ | IRAK4 | Q9NWZ3 | 9/20 | 0.43 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.41 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.41 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | RET | P07949 | 1/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | CDK7 | P50613 | 1/20 | 0.40 |
| ▸ | BLK | P51451 | 1/20 | 0.40 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.40 |
| ▸ | CCNH | P51946 | 1/20 | 0.40 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24574132 | 1.00 | FLT3 (0.47) | FLT3IRAK4CCNT1TRPV3FGFR3 | |
| SCHEMBL24573974 | 0.95 | FLT3 (0.48) | FLT3IRAK4CCNT1USP30LCK | |
| SCHEMBL24574401 | 0.90 | FLT3 (0.47) | FLT3IRAK4CCNT1TRPV3USP30 | |
| SCHEMBL24574400 | 0.90 | FLT3 (0.47) | FLT3IRAK4CCNT1TRPV3USP30 | |
| SCHEMBL24573973 | 0.87 | FLT3 (0.54) | FLT3IRAK4CCNT1USP30LCK | |
| SCHEMBL24573975 | 0.87 | FLT3 (0.54) | FLT3IRAK4CCNT1USP30LCK | |
| SCHEMBL24574365 | 0.86 | FLT3 (0.48) | FLT3IRAK4CCNT1FGFR3KDR | |
| SCHEMBL24574511 | 0.86 | FLT3 (0.53) | FLT3IRAK4CCNT1USP30LCK | |
| SCHEMBL24574166 | 0.85 | FLT3 (0.49) | FLT3IRAK4CCNT1USP30LCK | |
| SCHEMBL24573969 | 0.85 | FLT3 (0.42) | FLT3IRAK4CCNT1FGFR3KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022140647-A1 | MULTI-CYCLIC IRAK AND FLT3 INHIBITING COMPOUNDS AND USES THEREOF | CHILDREN'S HOSPITAL MEDICAL CENTER (US) | 2022-06-30 | — | — | WO | disclosed |