Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.47 |
| ▸ | FLT3 | P36888 | 6/20 | 0.47 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.45 |
| ▸ | IRAK4 | Q9NWZ3 | 6/20 | 0.44 |
| ▸ | CDK2 | P24941 | 2/20 | 0.44 |
| ▸ | JUN | P05412 | 1/20 | 0.44 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.44 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.44 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.44 |
| ▸ | SYK | P43405 | 1/20 | 0.43 |
| ▸ | IDH1 | O75874 | 1/20 | 0.43 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24231865 | 0.90 | IRAK4 (0.56) | USP30FLT3CCNT1IRAK4CDK2 | |
| SCHEMBL24231869 | 0.87 | FLT3 (0.58) | USP30FLT3CCNT1IRAK4IDH1 | |
| SCHEMBL24231604 | 0.87 | FLT3 (0.58) | USP30FLT3CCNT1IRAK4IDH1 | |
| SCHEMBL24574190 | 0.86 | FLT3 (0.51) | USP30FLT3CCNT1IRAK4SYK | |
| SCHEMBL24232046 | 0.86 | FLT3 (0.47) | USP30FLT3CCNT1IRAK4SYK | |
| SCHEMBL24574511 | 0.86 | FLT3 (0.53) | USP30FLT3CCNT1IRAK4IDH1 | |
| SCHEMBL24574159 | 0.86 | FLT3 (0.51) | USP30FLT3CCNT1IRAK4SYK | |
| SCHEMBL24574154 | 0.86 | FLT3 (0.51) | USP30FLT3CCNT1IRAK4SYK | |
| SCHEMBL24231463 | 0.85 | IRAK4 (0.48) | USP30FLT3CCNT1IRAK4IDH1 | |
| SCHEMBL24542493 | 0.85 | USP30 (0.47) | USP30FLT3CCNT1IRAK4SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022140647-A1 | MULTI-CYCLIC IRAK AND FLT3 INHIBITING COMPOUNDS AND USES THEREOF | CHILDREN'S HOSPITAL MEDICAL CENTER (US) | 2022-06-30 | — | — | WO | disclosed |