Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLQ | O75417 | 2/20 | 0.37 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.33 |
| ▸ | CDK9 | P50750 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 2/20 | 0.33 |
| ▸ | WNT1 | P04628 | 2/20 | 0.32 |
| ▸ | GSK3B | P49841 | 2/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.32 |
| ▸ | GPR6 | P46095 | 2/20 | 0.32 |
| ▸ | WNT3A | P56704 | 1/20 | 0.31 |
| ▸ | OGA | O60502 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27185013 | 0.99 | POLQ (0.37) | POLQIRAK4CHRM1PDGFRAHRH3 | |
| SCHEMBL29759540 | 0.99 | POLQ (0.37) | POLQIRAK4CHRM1PDGFRAHRH3 | |
| SCHEMBL29760033 | 0.99 | POLQ (0.37) | POLQIRAK4CHRM1PDGFRAHRH3 | |
| SCHEMBL24577376 | 0.99 | POLQ (0.37) | POLQIRAK4CHRM1PDGFRAHRH3 | |
| SCHEMBL29759526 | 0.99 | POLQ (0.37) | POLQIRAK4CHRM1PDGFRAHRH3 | |
| SCHEMBL27184973 | 0.99 | POLQ (0.37) | POLQIRAK4CHRM1PDGFRAHRH3 | |
| SCHEMBL29759444 | 0.93 | IRAK4 (0.36) | POLQIRAK4CHRM1PDGFRAHRH3 | |
| SCHEMBL24579115 | 0.93 | POLQ (0.35) | POLQIRAK4CHRM1PDGFRAHRH3 | |
| SCHEMBL29759754 | 0.93 | POLQ (0.35) | POLQIRAK4CHRM1PDGFRAHRH3 | |
| SCHEMBL24577390 | 0.92 | IRAK4 (0.35) | POLQIRAK4CHRM1PDGFRAHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022136509-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2022-06-30 | — | — | WO | disclosed |