Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKE | Q14164 | 7/20 | 0.36 |
| ▸ | TBK1 | Q9UHD2 | 7/20 | 0.36 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.34 |
| ▸ | KAT5 | Q92993 | 1/20 | 0.33 |
| ▸ | KIT | P10721 | 2/20 | 0.33 |
| ▸ | GSK3B | P49841 | 2/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 2/20 | 0.31 |
| ▸ | JAK3 | P52333 | 2/20 | 0.31 |
| ▸ | JAK1 | P23458 | 1/20 | 0.31 |
| ▸ | TYK2 | P29597 | 1/20 | 0.31 |
| ▸ | BTK | Q06187 | 1/20 | 0.31 |
| ▸ | CSF1R | P07333 | 1/20 | 0.30 |
| ▸ | LIPC | P11150 | 1/20 | 0.30 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.30 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.30 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.30 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.30 |
| ▸ | RET | P07949 | 1/20 | 0.30 |
| ▸ | CDK2 | P24941 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29759795 | 1.00 | IKBKE (0.36) | IKBKETBK1USP30KAT5KIT | |
| SCHEMBL29759475 | 1.00 | IKBKE (0.36) | IKBKETBK1USP30KAT5KIT | |
| SCHEMBL30566543 | 1.00 | IKBKE (0.36) | IKBKETBK1USP30KAT5KIT | |
| SCHEMBL24577578 | 1.00 | IKBKE (0.36) | IKBKETBK1USP30KAT5KIT | |
| SCHEMBL24577720 | 0.91 | GSK3B (0.38) | USP30KITGSK3BDYRK1ACSF1R | |
| SCHEMBL24577577 | 0.91 | GSK3B (0.38) | USP30KITGSK3BDYRK1ACSF1R | |
| SCHEMBL29759770 | 0.91 | GSK3B (0.38) | USP30KITGSK3BDYRK1ACSF1R | |
| SCHEMBL29760106 | 0.91 | GSK3B (0.38) | USP30KITGSK3BDYRK1ACSF1R | |
| SCHEMBL30566605 | 0.91 | GSK3B (0.38) | USP30KITGSK3BDYRK1ACSF1R | |
| SCHEMBL27185042 | 0.91 | GSK3B (0.38) | USP30KITGSK3BDYRK1ACSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022136509-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2022-06-30 | — | — | WO | disclosed |