Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.33 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.33 |
| ▸ | MET | P08581 | 1/20 | 0.31 |
| ▸ | AXL | P30530 | 1/20 | 0.31 |
| ▸ | CSF1R | P07333 | 1/20 | 0.31 |
| ▸ | KIT | P10721 | 1/20 | 0.31 |
| ▸ | WNT1 | P04628 | 1/20 | 0.30 |
| ▸ | GSK3B | P49841 | 1/20 | 0.30 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.30 |
| ▸ | AURKA | O14965 | 1/20 | 0.30 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29759641 | 1.00 | CHRM1 (0.38) | CHRM1PDGFRAHRH3IKBKETBK1 | |
| SCHEMBL29759679 | 0.98 | CHRM1 (0.40) | CHRM1PDGFRAHRH3IKBKETBK1 | |
| SCHEMBL29759518 | 0.97 | CHRM1 (0.40) | CHRM1PDGFRAHRH3IKBKETBK1 | |
| SCHEMBL24577036 | 0.97 | CHRM1 (0.40) | CHRM1PDGFRAHRH3IKBKETBK1 | |
| SCHEMBL24577428 | 0.91 | PDGFRA (0.46) | CHRM1PDGFRAHRH3IKBKETBK1 | |
| SCHEMBL29759499 | 0.91 | PDGFRA (0.46) | CHRM1PDGFRAHRH3CSF1RKIT | |
| SCHEMBL24577313 | 0.91 | CHRM1 (0.39) | CHRM1PDGFRAHRH3IKBKETBK1 | |
| SCHEMBL29759945 | 0.91 | CHRM1 (0.39) | CHRM1PDGFRAHRH3IKBKETBK1 | |
| SCHEMBL29760198 | 0.90 | CHRM1 (0.35) | CHRM1PDGFRAHRH3METAXL | |
| SCHEMBL24577260 | 0.89 | IKBKE (0.37) | CHRM1PDGFRAHRH3IKBKETBK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022136509-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2022-06-30 | — | — | WO | disclosed |