Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | CSF1R | P07333 | 1/20 | 0.37 |
| ▸ | KIT | P10721 | 1/20 | 0.37 |
| ▸ | TERT | O14746 | 1/20 | 0.34 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.33 |
| ▸ | WNT1 | P04628 | 3/20 | 0.33 |
| ▸ | GSK3B | P49841 | 3/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.33 |
| ▸ | PIM1 | P11309 | 1/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.32 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.32 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 4/20 | 0.32 |
| ▸ | JAK1 | P23458 | 4/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.32 |
| ▸ | AXL | P30530 | 1/20 | 0.32 |
| ▸ | MERTK | Q12866 | 1/20 | 0.32 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29759804 | 1.00 | CHRM1 (0.39) | CHRM1PDGFRAHRH3CSF1RKIT | |
| SCHEMBL27185094 | 0.93 | CHRM1 (0.37) | CHRM1PDGFRAHRH3CSF1RKIT | |
| SCHEMBL29759854 | 0.91 | IKBKE (0.37) | CHRM1PDGFRAHRH3JAK2JAK1 | |
| SCHEMBL24577580 | 0.91 | IKBKE (0.37) | CHRM1PDGFRAHRH3JAK2JAK1 | |
| SCHEMBL29759732 | 0.89 | CHRM1 (0.35) | CHRM1PDGFRAHRH3CSF1RKIT | |
| SCHEMBL24579044 | 0.89 | CHRM1 (0.35) | CHRM1PDGFRAHRH3CSF1RKIT | |
| SCHEMBL24578984 | 0.88 | CHRM3 (0.41) | CHRM3 | |
| SCHEMBL24577511 | 0.88 | CHRM1 (0.37) | CHRM1PDGFRAHRH3CSF1RKIT | |
| SCHEMBL24578982 | 0.88 | CHRM3 (0.41) | CHRM3 | |
| SCHEMBL24577725 | 0.88 | CHRM3 (0.41) | CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022136509-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2022-06-30 | — | — | WO | disclosed |