Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 13/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 13/20 | 0.37 |
| ▸ | WNT1 | P04628 | 12/20 | 0.37 |
| ▸ | CSF1R | P07333 | 1/20 | 0.36 |
| ▸ | KIT | P10721 | 1/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 4/20 | 0.35 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29760094 | 1.00 | CHRM1 (0.39) | CHRM1PDGFRAHRH3GSK3BDYRK1A | |
| SCHEMBL24577827 | 0.91 | GSK3B (0.43) | CHRM1PDGFRAHRH3GSK3BDYRK1A | |
| SCHEMBL24577139 | 0.87 | GSK3B (0.44) | CHRM1PDGFRAHRH3GSK3BDYRK1A | |
| SCHEMBL29759460 | 0.87 | GSK3B (0.47) | CHRM1PDGFRAHRH3GSK3BDYRK1A | |
| SCHEMBL29759484 | 0.87 | GSK3B (0.47) | CHRM1PDGFRAHRH3GSK3BDYRK1A | |
| SCHEMBL24577030 | 0.87 | GSK3B (0.38) | CHRM1PDGFRAHRH3GSK3BDYRK1A | |
| SCHEMBL29760208 | 0.87 | GSK3B (0.38) | CHRM1PDGFRAHRH3GSK3BDYRK1A | |
| SCHEMBL29759990 | 0.86 | GSK3B (0.49) | CHRM1PDGFRAHRH3GSK3BDYRK1A | |
| SCHEMBL24578483 | 0.86 | GSK3B (0.49) | CHRM1PDGFRAHRH3GSK3BDYRK1A | |
| SCHEMBL29759759 | 0.86 | GSK3B (0.49) | CHRM1PDGFRAHRH3GSK3BDYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022136509-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2022-06-30 | — | — | WO | disclosed |