Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRA | P16234 | 4/20 | 0.64 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.64 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.64 |
| ▸ | PDE10A | Q9Y233 | 5/20 | 0.35 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.34 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.34 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | BCR | P11274 | 1/20 | 0.33 |
| ▸ | KIT | P10721 | 2/20 | 0.33 |
| ▸ | FLT3 | P36888 | 1/20 | 0.33 |
| ▸ | CSF1R | P07333 | 1/20 | 0.32 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29760020 | 1.00 | PDGFRA (0.64) | PDGFRACHRM1HRH3PDE10AMAPK13 | |
| SCHEMBL24578594 | 0.93 | PDGFRA (0.66) | PDGFRACHRM1HRH3PDE10AMAPK13 | |
| SCHEMBL29759529 | 0.93 | PDGFRA (0.66) | PDGFRACHRM1HRH3PDE10AMAPK13 | |
| SCHEMBL29760038 | 0.92 | PDGFRA (0.64) | PDGFRACHRM1HRH3KITCSF1R | |
| SCHEMBL24577956 | 0.92 | PDGFRA (0.64) | PDGFRACHRM1HRH3KITCSF1R | |
| SCHEMBL29759627 | 0.92 | PDGFRA (0.68) | PDGFRACHRM1HRH3MAPK13MAPK12 | |
| SCHEMBL29759785 | 0.91 | PDGFRA (0.62) | PDGFRACHRM1HRH3PDE10AKIT | |
| SCHEMBL24577877 | 0.90 | PDGFRA (0.73) | PDGFRACHRM1HRH3KITCSF1R | |
| SCHEMBL29759503 | 0.90 | PDGFRA (0.73) | PDGFRACHRM1HRH3KITCSF1R | |
| SCHEMBL24578027 | 0.90 | PDGFRA (0.67) | PDGFRACHRM1HRH3MAPK14ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022136509-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2022-06-30 | — | — | WO | disclosed |