Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRA | P16234 | 2/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | CSF1R | P07333 | 1/20 | 0.38 |
| ▸ | KIT | P10721 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 6/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 6/20 | 0.36 |
| ▸ | WNT1 | P04628 | 4/20 | 0.36 |
| ▸ | KIF18A | Q8NI77 | 1/20 | 0.32 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.32 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.31 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.31 |
| ▸ | OGA | O60502 | 4/20 | 0.31 |
| ▸ | RAF1 | P04049 | 2/20 | 0.31 |
| ▸ | BRAF | P15056 | 2/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29759700 | 1.00 | PDGFRA (0.40) | PDGFRACHRM1HRH3CSF1RKIT | |
| SCHEMBL29759948 | 0.96 | PDGFRA (0.41) | PDGFRACHRM1HRH3CSF1RKIT | |
| SCHEMBL29759924 | 0.91 | IKBKE (0.37) | PDGFRACHRM1HRH3CSF1RKIT | |
| SCHEMBL24577065 | 0.91 | IKBKE (0.37) | PDGFRACHRM1HRH3CSF1RKIT | |
| SCHEMBL29759814 | 0.90 | CHRM1 (0.40) | PDGFRACHRM1HRH3CSF1RKIT | |
| SCHEMBL29759697 | 0.89 | CHRM1 (0.35) | PDGFRACHRM1HRH3CSF1RKIT | |
| SCHEMBL29759866 | 0.89 | IKBKE (0.36) | PDGFRACHRM1HRH3CSF1RKIT | |
| SCHEMBL29759494 | 0.89 | CHRM1 (0.39) | PDGFRACHRM1HRH3CSF1RKIT | |
| SCHEMBL29760004 | 0.87 | GSK3B (0.41) | PDGFRACHRM1HRH3CSF1RKIT | |
| SCHEMBL29759511 | 0.87 | CHRM1 (0.38) | PDGFRACHRM1HRH3CSF1RKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022136509-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2022-06-30 | — | — | WO | disclosed |