Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 16/20 | 0.36 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | STAT3 | P40763 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24577880 | 0.87 | HDAC6 (0.36) | HDAC6ALDH1A1 | |
| SCHEMBL24578933 | 0.86 | HDAC6 (0.35) | HDAC6ALDH1A1 | |
| SCHEMBL24578875 | 0.84 | EPHB3 (0.35) | FGFR4STAT3NPC1ALDH1A1RAB9A | |
| SCHEMBL24578499 | 0.80 | PDGFRA (0.40) | RETFGFR4 | |
| SCHEMBL24577081 | 0.80 | HDAC6 (0.37) | HDAC6 | |
| SCHEMBL24578458 | 0.78 | HDAC6 (0.36) | HDAC6 | |
| SCHEMBL24577161 | 0.77 | HDAC6 (0.39) | HDAC6 | |
| SCHEMBL24577029 | 0.74 | HDAC6 (0.37) | HDAC6 | |
| SCHEMBL24577338 | 0.71 | HDAC6 (0.39) | HDAC6 | |
| SCHEMBL24576968 | 0.71 | BRD4 (0.41) | HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4267585-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | Actelion Pharmaceuticals Ltd (CH) | 2023-11-01 | — | — | EP | disclosed |
| WO-2022136509-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2022-06-30 | — | — | WO | disclosed |
| WO-2022136509-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2022-06-30 | — | — | WO | disclosed |