Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | CTSK | P43235 | 2/20 | 0.47 |
| ▸ | F2 | P00734 | 1/20 | 0.45 |
| ▸ | F10 | P00742 | 1/20 | 0.45 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.44 |
| ▸ | RELA | Q04206 | 1/20 | 0.44 |
| ▸ | BTK | Q06187 | 1/20 | 0.43 |
| ▸ | NAAA | Q02083 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | HPGDS | O60760 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.39 |
| ▸ | FPR2 | P25090 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21887787 | 1.00 | GAA (0.49) | GAACTSKF2F10PRSS1 | |
| SCHEMBL4099515 | 1.00 | GAA (0.49) | GAACTSKF2F10PRSS1 | |
| SCHEMBL4099514 | 1.00 | GAA (0.49) | GAACTSKF2F10PRSS1 | |
| SCHEMBL4097703 | 0.91 | F2 (0.48) | GAACTSKF2F10PRSS1 | |
| SCHEMBL2386997 | 0.91 | F2 (0.48) | GAACTSKF2F10PRSS1 | |
| SCHEMBL2386992 | 0.91 | F2 (0.48) | GAACTSKF2F10PRSS1 | |
| SCHEMBL2456099 | 0.90 | GAA (0.46) | GAACTSKF2F10PRSS1 | |
| SCHEMBL2456097 | 0.90 | GAA (0.46) | GAACTSKF2F10PRSS1 | |
| SCHEMBL5637239 | 0.90 | GAA (0.46) | GAACTSKF2F10PRSS1 | |
| SCHEMBL2460778 | 0.90 | GAA (0.46) | GAACTSKF2F10PRSS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8026233-B2 | P38 inhibitors and methods of use thereof | ARRAY BIOPHARMA INC. (US) | 2011-09-27 | — | — | US | disclosed |