Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 3/20 | 0.64 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.64 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.64 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.64 |
| ▸ | PBK | Q96KB5 | 11/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1581071 | 0.95 | PDE4A (0.63) | PDE4APDE4BPDE4CPDE4DPBK | |
| SCHEMBL1554160 | 0.90 | PDE4A (0.56) | PDE4APDE4BPDE4CPDE4DPBK | |
| Hydrochloric Acid SCHEMBL8576071 | 0.89 | PDE4A (0.55) | PDE4APDE4BPDE4CPDE4DPBK | |
| SCHEMBL1581014 | 0.89 | PDE4A (0.66) | PDE4APDE4BPDE4CPDE4DPBK | |
| SCHEMBL1552957 | 0.85 | PDE4D (0.54) | PDE4APDE4BPDE4CPDE4DPBK | |
| Hydrochloric Acid SCHEMBL8568573 | 0.84 | PDE4D (0.53) | PDE4APDE4BPDE4CPDE4DPBK | |
| SCHEMBL2318486 | 0.84 | PDE4A (0.65) | PDE4APDE4BPDE4CPDE4DPBK | |
| SCHEMBL8571281 | 0.82 | PDE4A (0.46) | PDE4APDE4BPDE4CPDE4DPBK | |
| SCHEMBL1581259 | 0.82 | PBK (0.61) | PDE4APDE4BPDE4CPDE4DPBK | |
| SCHEMBL1554161 | 0.81 | PDE4A (0.58) | PDE4APDE4BPDE4CPDE4DPBK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2364087-A1 | 7-HYDROXY-BENZOIMIDAZOLE-4-YL-METHANONE DERIVATIVES AND PBK INHIBITORS CONTAINING THE SAME | Oncotherapy Science, Inc. (JP) | 2011-09-14 | — | — | EP | disclosed |
| WO-2010051085-A1 | 7-HYDROXY-BENZOIMIDAZOLE-4-YL-METHANONE DERIVATIVES AND PBK INHIBITORS CONTAINING THE SAME | ONCOTHERAPY SCIENCE, INC. (JP) | 2010-05-06 | — | — | WO | disclosed |