Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASR | P41180 | 12/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | HTR1A | P08908 | 1/20 | 0.48 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.48 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.48 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.48 |
| ▸ | HRH2 | P25021 | 1/20 | 0.48 |
| ▸ | HTR2A | P28223 | 1/20 | 0.48 |
| ▸ | HTR2C | P28335 | 1/20 | 0.48 |
| ▸ | HRH1 | P35367 | 1/20 | 0.48 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.48 |
| ▸ | DRD3 | P35462 | 1/20 | 0.48 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.48 |
| ▸ | HTR2B | P41595 | 1/20 | 0.48 |
| ▸ | HTR5A | P47898 | 1/20 | 0.48 |
| ▸ | HTR6 | P50406 | 1/20 | 0.48 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.48 |
| ▸ | GPR65 | Q8IYL9 | 1/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4993611 | 0.86 | CASR (0.65) | CASRHTR1AHTR5AKMT2AMEN1 | |
| SCHEMBL8200312 | 0.86 | CASR (0.65) | CASRHTR1AHTR5AKMT2AMEN1 | |
| SCHEMBL16225218 | 0.85 | KMT2A (0.54) | CASRKMT2AMEN1NPC1RAB9A | |
| SCHEMBL16225176 | 0.85 | KMT2A (0.54) | CASRKMT2AMEN1NPC1RAB9A | |
| SCHEMBL2461100 | 0.82 | CASR (0.61) | CASRHTR1AADRA2BADRA2CSLC6A2 | |
| SCHEMBL12786223 | 0.81 | KDM4E (0.54) | CASRSMN1; SMN2HTR1ASLC6A2OPRM1 | |
| SCHEMBL12473521 | 0.81 | KDM4E (0.54) | CASRSMN1; SMN2HTR1ASLC6A2OPRM1 | |
| SCHEMBL3926119 | 0.80 | CASR (0.68) | CASRSMN1; SMN2HTR1AADRA2BADRA2C | |
| SCHEMBL2458998 | 0.79 | CASR (0.61) | CASRSMN1; SMN2HTR1AADRA2BADRA2C | |
| SCHEMBL2461168 | 0.78 | CASR (0.61) | CASRSMN1; SMN2HTR1AADRA2BADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110230517-A1 | CALCIUM RECEPTOR MODULATING AGENTS | AMGEN INC. | 2011-09-22 | — | — | US | claimed |
| US-8791147-B2 | Calcium receptor modulating agents | AMGEN INC. (US) | 2014-07-29 | — | — | US | disclosed |
| US-8791147-B2 | Calcium receptor modulating agents | AMGEN INC. (US) | 2014-07-29 | — | — | US | disclosed |
| US-20110230517-A1 | CALCIUM RECEPTOR MODULATING AGENTS | AMGEN INC. | 2011-09-22 | — | — | US | disclosed |
| US-20110230517-A1 | CALCIUM RECEPTOR MODULATING AGENTS | AMGEN INC. | 2011-09-22 | — | — | US | disclosed |
| WO-2010042642-A1 | CALCIUM RECEPTOR MODULATING AGENTS | AMGEN INC. (US) | 2010-04-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110230517-A1 | CALCIUM RECEPTOR MODULATING AGENTS | CASR, CALCR, CNR1 | CASR 1/4885SMN1; SMN2 4049/4885HTR1A 352/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.