Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.36 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | DHODH | Q02127 | 3/20 | 0.35 |
| ▸ | GCGR | P47871 | 1/20 | 0.33 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL251684 | 1.00 | POLB (0.40) | POLBGRM2NR4A2MAPTDHODH | |
| SCHEMBL253741 | 0.91 | MAPT (0.40) | POLBGRM2NR4A2MAPTDHODH | |
| SCHEMBL251628 | 0.91 | MAPT (0.40) | POLBGRM2NR4A2MAPTDHODH | |
| SCHEMBL245588 | 0.82 | POLB (0.39) | POLBGRM2NR4A2DHODHGCGR | |
| SCHEMBL245587 | 0.82 | POLB (0.39) | POLBGRM2NR4A2DHODHGCGR | |
| SCHEMBL251939 | 0.82 | SYK (0.39) | NR4A2DHODH | |
| SCHEMBL244047 | 0.81 | NPC1 (0.39) | POLBGRM2MAPTDHODHKDM4E | |
| SCHEMBL244045 | 0.81 | NPC1 (0.39) | POLBGRM2MAPTDHODHKDM4E | |
| SCHEMBL244046 | 0.81 | NPC1 (0.39) | POLBGRM2MAPTDHODHKDM4E | |
| SCHEMBL27928091 | 0.80 | GCGR (0.37) | POLBGRM2DHODHGCGRCRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2588455-A1 | 2 -QUINOLINYL- ACETIC ACID DERIVATIVES AS HIV ANTIVIRAL COMPOUNDS | Gilead Sciences, Inc. (US) | 2013-05-08 | — | — | EP | disclosed |
| WO-2012003498-A1 | 2 -QUINOLINYL- ACETIC ACID DERIVATIVES AS HIV ANTIVIRAL COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2012-01-05 | — | — | WO | disclosed |