Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 16/20 | 0.76 |
| ▸ | WDR77 | Q9BQA1 | 5/20 | 0.76 |
| ▸ | METTL3 | Q86U44 | 9/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18571673 | 0.86 | PRMT5 (1.00) | PRMT5WDR77METTL3 | |
| SCHEMBL22495010 | 0.85 | PRMT5 (0.87) | PRMT5WDR77METTL3 | |
| SCHEMBL22509619 | 0.84 | PRMT5 (0.68) | PRMT5WDR77METTL3 | |
| SCHEMBL24254151 | 0.84 | PRMT5 (0.68) | PRMT5WDR77METTL3 | |
| SCHEMBL31123435 | 0.80 | PRMT5 (0.71) | PRMT5WDR77METTL3 | |
| SCHEMBL21683375 | 0.80 | PRMT5 (0.69) | PRMT5WDR77METTL3 | |
| SCHEMBL31361574 | 0.80 | PRMT5 (0.69) | PRMT5WDR77METTL3 | |
| SCHEMBL18572237 | 0.79 | PRMT5 (0.79) | PRMT5WDR77METTL3 | |
| SCHEMBL18572242 | 0.79 | PRMT5 (0.79) | PRMT5WDR77METTL3 | |
| SCHEMBL22002126 | 0.79 | PRMT5 (0.72) | PRMT5WDR77METTL3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3724190-B1 | SUBSTITUTED BICYCLIC HETEROCYCLIC COMPOUNDS AS PRMT5 INHIBITORS | LUPIN LTD (IN) | 2022-07-06 | — | — | EP | disclosed |