Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOS1 | Q07889 | 16/20 | 0.45 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.33 |
| ▸ | CDK9 | P50750 | 1/20 | 0.33 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.33 |
| ▸ | CTSL | P07711 | 1/20 | 0.33 |
| ▸ | CTSB | P07858 | 1/20 | 0.33 |
| ▸ | CTSS | P25774 | 1/20 | 0.33 |
| ▸ | CTSK | P43235 | 1/20 | 0.33 |
| ▸ | KRAS | P01116 | 5/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.32 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29691318 | 1.00 | SOS1 (0.45) | SOS1CCNT1CDK9FTOCTSL | |
| SCHEMBL24597107 | 0.87 | SOS1 (0.43) | SOS1CCNT1CDK9FTOCTSL | |
| SCHEMBL29691265 | 0.87 | SOS1 (0.43) | SOS1CCNT1CDK9FTOCTSL | |
| SCHEMBL29691341 | 0.85 | SOS1 (0.45) | SOS1CCNT1CDK9FTOCTSL | |
| SCHEMBL24597173 | 0.85 | SOS1 (0.45) | SOS1CCNT1CDK9FTOCTSL | |
| Hydrochloric Acid SCHEMBL29691278 | 0.85 | SOS1 (0.46) | SOS1FTOCTSLCTSBCTSS | |
| SCHEMBL24597167 | 0.83 | SOS1 (0.45) | SOS1KRAS | |
| SCHEMBL24597158 | 0.81 | SOS1 (0.43) | SOS1CCNT1CDK9 | |
| SCHEMBL29691281 | 0.81 | SOS1 (0.43) | SOS1CCNT1CDK9 | |
| SCHEMBL24597164 | 0.80 | SOS1 (0.44) | SOS1FTOCTSLCTSBCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022146698-A1 | SOS1 INHIBITORS AND USES THEREOF | Revolution Medicines, Inc. (US) | 2022-07-07 | — | — | WO | disclosed |