Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CKS1B | P61024 | 1/20 | 0.48 |
| ▸ | SKP1 | P63208 | 1/20 | 0.48 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.48 |
| ▸ | JAK1 | P23458 | 4/20 | 0.45 |
| ▸ | JAK2 | O60674 | 3/20 | 0.45 |
| ▸ | PIM1 | P11309 | 1/20 | 0.44 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.44 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 2/20 | 0.43 |
| ▸ | RET | P07949 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
| ▸ | OGFRL1 | Q5TC84 | 1/20 | 0.42 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.41 |
| ▸ | TYK2 | P29597 | 1/20 | 0.41 |
| ▸ | JAK3 | P52333 | 1/20 | 0.41 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29691572 | 1.00 | CKS1B (0.48) | CKS1BSKP1SKP2JAK1JAK2 | |
| SCHEMBL29691669 | 0.87 | CKS1B (0.40) | CKS1BSKP1SKP2JAK1JAK2 | |
| SCHEMBL24601082 | 0.87 | CKS1B (0.40) | CKS1BSKP1SKP2JAK1JAK2 | |
| SCHEMBL24600959 | 0.86 | CKS1B (0.50) | CKS1BSKP1SKP2JAK1JAK2 | |
| SCHEMBL29691484 | 0.86 | CKS1B (0.50) | CKS1BSKP1SKP2JAK1JAK2 | |
| SCHEMBL24601078 | 0.85 | SIRT2 (0.47) | CKS1BSKP1SKP2JAK1JAK2 | |
| SCHEMBL29691616 | 0.85 | SIRT2 (0.47) | CKS1BSKP1SKP2JAK1JAK2 | |
| SCHEMBL1002827 | 0.85 | AKT2 (0.58) | CKS1BSKP1SKP2JAK1JAK2 | |
| SCHEMBL21173533 | 0.81 | CKS1B (0.56) | CKS1BSKP1SKP2JAK1JAK2 | |
| SCHEMBL24600618 | 0.81 | CA12 (0.40) | CKS1BSKP1SKP2JAK1JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4276100-A1 | NOVEL NAPHTHYRIDINONE DERIVATIVE HAVING INHIBITORY ACTIVITY AGAINST ECTONUCLEOTIDE PYROPHOSPHATASE-PHOSPHODIESTERASE AND USE THEREOF | Txinno Bioscience Inc. (KR) | 2023-11-15 | — | — | EP | disclosed |
| EP-4276100-A1 | NOVEL NAPHTHYRIDINONE DERIVATIVE HAVING INHIBITORY ACTIVITY AGAINST ECTONUCLEOTIDE PYROPHOSPHATASE-PHOSPHODIESTERASE AND USE THEREOF | Txinno Bioscience Inc. (KR) | 2023-11-15 | — | — | EP | disclosed |
| WO-2022146022-A1 | NOVEL NAPHTHYRIDINONE DERIVATIVE HAVING INHIBITORY ACTIVITY AGAINST ECTONUCLEOTIDE PYROPHOSPHATASE-PHOSPHODIESTERASE AND USE THEREOF | 주식회사 티씨노바이오사이언스 | 2022-07-07 | — | — | WO | disclosed |