Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.34 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | HTR1B | P28222 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25466829 | 0.84 | KDM4E (0.36) | KDM4EPOLBTDP1CYP1A2CYP2D6 | |
| SCHEMBL22906464 | 0.84 | KDM4E (0.36) | KDM4EPOLBTDP1CYP1A2CYP2D6 | |
| SCHEMBL24622158 | 0.84 | KDM4E (0.36) | KDM4EPOLBTDP1CYP1A2CYP2D6 | |
| SCHEMBL10914222 | 0.82 | KDM4E (0.44) | KDM4EPOLBTDP1ADRB2ADRB1 | |
| SCHEMBL22930120 | 0.82 | KDM4E (0.44) | KDM4EPOLBTDP1ADRB2ADRB1 | |
| SCHEMBL13604089 | 0.82 | HSD17B10 (0.40) | TDP1HSD17B10 | |
| SCHEMBL22837632 | 0.82 | KDM4E (0.44) | KDM4EPOLBTDP1ADRB2ADRB1 | |
| SCHEMBL18908756 | 0.82 | KDM4E (0.44) | KDM4EPOLBTDP1ADRB2ADRB1 | |
| SCHEMBL18908660 | 0.82 | KDM4E (0.44) | KDM4EPOLBTDP1ADRB2ADRB1 | |
| SCHEMBL18908652 | 0.82 | KDM4E (0.44) | KDM4EPOLBTDP1ADRB2ADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022147465-A1 | IRAK DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2022-07-07 | — | — | WO | disclosed |