Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | CXCR4 | P61073 | 2/20 | 0.46 |
| ▸ | ACHE | P22303 | 3/20 | 0.44 |
| ▸ | BACE1 | P56817 | 2/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.43 |
| ▸ | FAAH | O00519 | 1/20 | 0.42 |
| ▸ | BCHE | P06276 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.41 |
| ▸ | CCR3 | P51677 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26409040 | 0.86 | KCNH2 (0.54) | L3MBTL1CXCR4ACHEBACE1KCNH2 | |
| SCHEMBL23696174 | 0.84 | BCHE (0.49) | MAOBCXCR4ACHEBACE1FAAH | |
| SCHEMBL13428851 | 0.84 | CXCR4 (0.64) | MAOBCXCR4ACHEBACE1CCR3 | |
| SCHEMBL25923799 | 0.82 | CXCR4 (0.40) | CXCR4ACHEBACE1HRH3 | |
| SCHEMBL23696175 | 0.79 | S1PR1 (0.52) | HRH3 | |
| SCHEMBL25654352 | 0.76 | BCHE (0.45) | MAOBCXCR4ACHEFAAHBCHE | |
| SCHEMBL8227566 | 0.76 | CXCR4 (0.54) | CXCR4ACHEBACE1BCHECCR3 | |
| SCHEMBL25927715 | 0.76 | BCHE (0.47) | MAOBCXCR4ACHEFAAHBCHE | |
| SCHEMBL13228061 | 0.75 | HRH3 (0.68) | L3MBTL1CXCR4HRH3 | |
| SCHEMBL22549603 | 0.74 | CCR3 (0.77) | L3MBTL1KCNH2CCR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022147465-A1 | IRAK DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2022-07-07 | — | — | WO | disclosed |