Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 11/20 | 0.44 |
| ▸ | CRBN | Q96SW2 | 11/20 | 0.44 |
| ▸ | JAK1 | P23458 | 2/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29751169 | 1.00 | DDB1 (0.44) | DDB1CRBNJAK1CYP11B2HDAC1 | |
| SCHEMBL24607600 | 0.95 | DDB1 (0.44) | DDB1CRBNJAK1CYP11B2HDAC1 | |
| SCHEMBL29751579 | 0.95 | DDB1 (0.44) | DDB1CRBNJAK1CYP11B2HDAC1 | |
| SCHEMBL29751140 | 0.86 | DDB1 (0.48) | DDB1CRBNCYP11B2GPR119 | |
| SCHEMBL24607451 | 0.86 | DDB1 (0.48) | DDB1CRBNCYP11B2GPR119 | |
| SCHEMBL24607781 | 0.81 | PARP1 (0.46) | DDB1CRBNCYP11B2HDAC1GPR119 | |
| SCHEMBL29751385 | 0.81 | PARP1 (0.46) | DDB1CRBNCYP11B2HDAC1GPR119 | |
| SCHEMBL24508854 | 0.81 | DDB1 (0.44) | DDB1CRBNCYP11B2 | |
| SCHEMBL30545177 | 0.81 | DDB1 (0.44) | DDB1CRBNCYP11B2 | |
| SCHEMBL29709781 | 0.81 | DDB1 (0.44) | DDB1CRBNCYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022147465-A1 | IRAK DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2022-07-07 | — | — | WO | disclosed |