Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 7/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 4/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.37 |
| ▸ | PRKDC | P78527 | 2/20 | 0.37 |
| ▸ | MTOR | P42345 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | STS | P08842 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CRHBP | P24387 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29751135 | 1.00 | TP53 (0.40) | TP53ALDH1A1HTTLMNABACE1 | |
| SCHEMBL29751042 | 0.93 | TP53 (0.41) | TP53ALDH1A1HTTLMNABACE1 | |
| SCHEMBL24608046 | 0.93 | TP53 (0.41) | TP53ALDH1A1HTTLMNABACE1 | |
| SCHEMBL31281923 | 0.92 | TP53 (0.40) | TP53ALDH1A1HTTLMNABACE1 | |
| SCHEMBL31443823 | 0.90 | TP53 (0.39) | TP53ALDH1A1HTTLMNABACE1 | |
| SCHEMBL31443994 | 0.89 | TP53 (0.38) | TP53ALDH1A1HTTLMNABACE1 | |
| SCHEMBL23832593 | 0.88 | TP53 (0.40) | TP53ALDH1A1HTTLMNABACE1 | |
| SCHEMBL24607322 | 0.88 | TP53 (0.40) | TP53ALDH1A1HTTLMNABACE1 | |
| SCHEMBL29751211 | 0.88 | TP53 (0.40) | TP53ALDH1A1HTTLMNABACE1 | |
| SCHEMBL31443924 | 0.87 | SMN1; SMN2 (0.41) | TP53ALDH1A1HTTLMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022147465-A1 | IRAK DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2022-07-07 | — | — | WO | disclosed |