Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 7/20 | 0.41 |
| ▸ | CRBN | Q96SW2 | 7/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 8/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31565145 | 1.00 | DDB1 (0.41) | DDB1CRBNGPR119KDM1ACYP11B2 | |
| SCHEMBL24508841 | 0.91 | DDB1 (0.47) | DDB1CRBNGPR119CYP11B2IDO1 | |
| SCHEMBL29709883 | 0.91 | DDB1 (0.47) | DDB1CRBNGPR119CYP11B2IDO1 | |
| SCHEMBL29751277 | 0.88 | DDB1 (0.43) | DDB1CRBNGPR119CYP11B2 | |
| SCHEMBL24608487 | 0.88 | DDB1 (0.43) | DDB1CRBNGPR119CYP11B2 | |
| SCHEMBL30627410 | 0.88 | DDB1 (0.43) | DDB1CRBNGPR119CYP11B2 | |
| SCHEMBL24608488 | 0.88 | DDB1 (0.43) | DDB1CRBNGPR119CYP11B2 | |
| SCHEMBL30318036 | 0.88 | DDB1 (0.43) | DDB1CRBNGPR119CYP11B2 | |
| SCHEMBL24608022 | 0.83 | CRBN (0.34) | DDB1CRBN | |
| SCHEMBL30627421 | 0.83 | CRBN (0.34) | DDB1CRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022147465-A1 | IRAK DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2022-07-07 | — | — | WO | disclosed |