SCHEMBL24613403

SCHEMBL24613403

C[C@](C=O)(CO)NCc1cc(Br)c(OCc2cccc(-c3cccc(COc4nc(OCc5cncc(C#N)c5)c(CN[C@](C)(CO)C(=O)O)cc4Br)c3Cl)c2Cl)nc1OCc1cncc(C#N)c1

nearest known ligand 0.54

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CD274 Q9NZQ7 20/20 0.54
PDCD1 Q15116 17/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24613666 1.00 CD274 (0.54) CD274PDCD1
SCHEMBL23949322 0.95 CD274 (0.58) CD274PDCD1
SCHEMBL20539277 0.95 CD274 (0.58) CD274PDCD1
SCHEMBL23949674 0.95 CD274 (0.58) CD274PDCD1
SCHEMBL24613401 0.95 CD274 (0.58) CD274PDCD1
SCHEMBL24613225 0.86 CD274 (0.50) CD274PDCD1
SCHEMBL24613839 0.84 CD274 (0.50) CD274PDCD1
SCHEMBL23949642 0.84 CD274 (0.50) CD274PDCD1
SCHEMBL23948845 0.84 CD274 (0.50) CD274PDCD1
SCHEMBL22023546 0.84 CD274 (0.50) CD274PDCD1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4026835-A2 PD-1/PD-L1 INHIBITORS Gilead Sciences, Inc. (US) 2022-07-13 EP disclosed