⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17449287 | 0.83 | — | — | |
| SCHEMBL1417527 | 0.79 | — | — | |
| SCHEMBL10631952 | 0.77 | MCL1 (0.36) | — | |
| SCHEMBL1417714 | 0.75 | — | — | |
| SCHEMBL11589733 | 0.74 | — | — | |
| SCHEMBL28099171 | 0.74 | — | — | |
| SCHEMBL23733932 | 0.72 | — | — | |
| SCHEMBL11184277 | 0.72 | — | — | |
| SCHEMBL8335317 | 0.72 | — | — | |
| SCHEMBL14765651 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 55 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3948915-A | 2-Halopyrimidine derivatives and a method for their preparation | DAIICHI SEIYAKU, CO., LTD. (JA) | 1976-04-06 | — | — | US | claimed |
| US-11110091-B2 | Modulators of toll-like receptors | GILEAD SCIENCES, INC. (US) | 2021-09-07 | — | — | US | disclosed |
| US-20190321366-A1 | MODULATORS OF TOLL-LIKE RECEPTORS | GILEAD SCIENCES, INC. | 2019-10-24 | — | — | US | disclosed |
| US-10172860-B2 | Modulators of toll-like receptors | GILEAD SCIENCES, INC. (US) | 2019-01-08 | — | — | US | disclosed |
| US-20180085370-A1 | MODULATORS OF TOLL-LIKE RECEPTORS | GILEAD SCIENCES, INC. | 2018-03-29 | — | — | US | disclosed |
| US-20180085370-A1 | MODULATORS OF TOLL-LIKE RECEPTORS | GILEAD SCIENCES, INC. | 2018-03-29 | — | — | US | disclosed |
| EP-3210982-A1 | MODULATORS OF TOLL-LIKE RECEPTORS | Gilead Sciences, Inc. (US) | 2017-08-30 | — | — | EP | disclosed |
| EP-3210982-A1 | MODULATORS OF TOLL-LIKE RECEPTORS | Gilead Sciences, Inc. (US) | 2017-08-30 | — | — | EP | disclosed |
| US-20170065592-A1 | MODULATORS OF TOLL-LIKE RECEPTORS | GILEAD SCIENCES, INC. | 2017-03-09 | — | — | US | disclosed |
| US-20170065592-A1 | MODULATORS OF TOLL-LIKE RECEPTORS | GILEAD SCIENCES, INC. | 2017-03-09 | — | — | US | disclosed |
| EP-2364314-A1 | MODULATORS OF TOLL-LIKE RECEPTORS | Gilead Sciences, Inc. (US) | 2011-09-14 | — | — | EP | disclosed |
| WO-2010077613-A1 | MODULATORS OF TOLL-LIKE RECEPTORS | GILEAD SCIENCES, INC. (US) | 2010-07-08 | — | — | WO | disclosed |
| WO-2010077613-A1 | MODULATORS OF TOLL-LIKE RECEPTORS | GILEAD SCIENCES, INC. (US) | 2010-07-08 | — | — | WO | disclosed |
| US-20100143301-A1 | MODULATORS OF TOLL-LIKE RECEPTORS | GILEAD SCIENCES, INC. (US) | 2010-06-10 | — | — | US | disclosed |
| US-20100143301-A1 | MODULATORS OF TOLL-LIKE RECEPTORS | GILEAD SCIENCES, INC. (US) | 2010-06-10 | — | — | US | disclosed |
| US-20100143301-A1 | MODULATORS OF TOLL-LIKE RECEPTORS | GILEAD SCIENCES, INC. (US) | 2010-06-10 | — | — | US | disclosed |
| US-4032559-A | PICKLING INHIBITORS, HYPOTENSIVE, SALTS OF MOTHPROOFING AGENTS | THE UPJOHN COMPANY (US) | 1977-06-28 | — | — | US | disclosed |
| US-4032559-A | PICKLING INHIBITORS, HYPOTENSIVE, SALTS OF MOTHPROOFING AGENTS | THE UPJOHN COMPANY (US) | 1977-06-28 | — | — | US | disclosed |
| US-3948915-A | 2-Halopyrimidine derivatives and a method for their preparation | DAIICHI SEIYAKU, CO., LTD. (JA) | 1976-04-06 | — | — | US | disclosed |
| US-3948915-A | 2-Halopyrimidine derivatives and a method for their preparation | DAIICHI SEIYAKU, CO., LTD. (JA) | 1976-04-06 | — | — | US | disclosed |