SCHEMBL24613698

CC(CO)(NCc1cc(Cl)c(O[C@H]2CCc3c(-c4cccc5c4CC[C@@H]5Oc4nc(OCc5cncc(S(C)(=O)=O)c5)c(CNC(C)(CO)C(=O)O)cc4Cl)cccc32)nc1OCc1cncc(S(C)(=O)=O)c1)C(=O)O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 2)

	gene	UniProt	supporting neighbours	confidence
▸	CD274	Q9NZQ7	20/20	1.00

▸	PDCD1	Q15116	15/20	1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL24613464	1.00	CD274 (1.00)	CD274PDCD1
SCHEMBL23949370	1.00	CD274 (1.00)	CD274PDCD1
SCHEMBL23948965	0.97	CD274 (0.94)	CD274PDCD1
SCHEMBL23949137	0.96	PDCD1 (0.92)	CD274PDCD1
SCHEMBL23949138	0.96	PDCD1 (0.92)	CD274PDCD1
SCHEMBL23949199	0.92	CD274 (0.85)	CD274PDCD1
SCHEMBL23949689	0.92	CD274 (0.84)	CD274PDCD1
SCHEMBL23949645	0.92	CD274 (0.84)	CD274PDCD1
SCHEMBL23949778	0.89	PDCD1 (0.80)	CD274PDCD1
SCHEMBL23949204	0.87	CD274 (0.77)	CD274PDCD1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-4026835-A2	PD-1/PD-L1 INHIBITORS	Gilead Sciences, Inc. (US)	2022-07-13	—	—	EP	disclosed