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Sugi Predict / Compounds / SCHEMBL24613756

SCHEMBL24613756

SCHEMBL24613756

COc1nc(OCc2cccc(-c3cccc(-c4ccc5c(c4)C[C@@H](N)C5)c3Cl)c2Cl)c(Br)cc1CNC(C)C(=O)O

nearest known ligand 0.49

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
▸ CD274 Q9NZQ7 20/20 0.49
▸ PDCD1 Q15116 12/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23949735 0.87 CD274 (0.48) CD274PDCD1
SCHEMBL24613070 0.87 CD274 (0.63) CD274PDCD1
SCHEMBL24613760 0.87 CD274 (0.50) CD274PDCD1
SCHEMBL24613757 0.87 CD274 (0.50) CD274PDCD1
SCHEMBL24613539 0.86 CD274 (0.54) CD274PDCD1
SCHEMBL23949381 0.86 CD274 (0.54) CD274PDCD1
SCHEMBL24613754 0.85 CD274 (0.51) CD274PDCD1
SCHEMBL23949412 0.85 CD274 (0.51) CD274PDCD1
SCHEMBL23949090 0.75 CD274 (0.63) CD274PDCD1
SCHEMBL23949234 0.71 CD274 (0.55) CD274PDCD1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4026835-A2 PD-1/PD-L1 INHIBITORS Gilead Sciences, Inc. (US) 2022-07-13 — — EP disclosed