Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Dopamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.66 |
| ▸ | MAPT | P10636 | 4/20 | 0.66 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.66 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.66 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.66 |
| ▸ | DRD2 | P14416 | 2/20 | 0.66 |
| ▸ | DRD1 | P21728 | 2/20 | 0.66 |
| ▸ | DRD4 | P21917 | 2/20 | 0.66 |
| ▸ | DRD5 | P21918 | 2/20 | 0.66 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.66 |
| ▸ | DRD3 | P35462 | 2/20 | 0.66 |
| ▸ | RECQL | P46063 | 2/20 | 0.66 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.66 |
| ▸ | APEX1 | P27695 | 2/20 | 0.66 |
| ▸ | THPO | P40225 | 2/20 | 0.66 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.66 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.66 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.66 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dopamine SCHEMBL5441164 | 0.87 | KDM4E (0.81) | KDM4EMAPTTDP1MAPK1ADRA2A | |
| Dopamine SCHEMBL3689353 | 0.86 | KDM4E (0.68) | KDM4EMAPTTDP1MAPK1ADRA2A | |
| Dopamine SCHEMBL20696071 | 0.86 | KDM4E (0.68) | KDM4EMAPTTDP1MAPK1ADRA2A | |
| Dopamine SCHEMBL9051903 | 0.85 | KDM4E (0.84) | KDM4EMAPTTDP1MAPK1ADRA2A | |
| Dopamine SCHEMBL28995038 | 0.85 | KDM4E (0.84) | KDM4EMAPTTDP1MAPK1ADRA2A | |
| Dopamine SCHEMBL30355306 | 0.85 | KDM4E (0.84) | KDM4EMAPTTDP1MAPK1ADRA2A | |
| Dopamine SCHEMBL28841647 | 0.84 | KDM4E (0.60) | KDM4EMAPTTDP1MAPK1ADRA2A | |
| Dopamine SCHEMBL29082656 | 0.83 | KDM4E (0.79) | KDM4EMAPTTDP1MAPK1ADRA2A | |
| 3,4-Dihydroxyphenylacetic Acid SCHEMBL8565392 | 0.82 | GAA (0.76) | KDM4EMAPTTDP1MAPK1ADRA2A | |
| Dopamine SCHEMBL28940538 | 0.82 | KDM4E (0.72) | KDM4EMAPTTDP1MAPK1ADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120003888-A1 | BIOADHESIVE CONSTRUCTS WITH POLYMER BLENDS | KNC NER ACQUISITION SUB, INC. (US) | 2012-01-05 | — | — | US | disclosed |
| EP-2334305-A1 | BIOADHESIVE CONSTRUCTS | KNC NER Acquisition Sub, Inc. (US) | 2011-06-22 | — | — | EP | disclosed |