Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 19/20 | 0.45 |
| ▸ | TYK2 | P29597 | 19/20 | 0.45 |
| ▸ | JAK2 | O60674 | 18/20 | 0.45 |
| ▸ | JAK3 | P52333 | 5/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29772748 | 1.00 | JAK1 (0.45) | JAK1TYK2JAK2JAK3EGFR | |
| SCHEMBL29772826 | 0.87 | JAK2 (0.57) | JAK1TYK2JAK2JAK3 | |
| SCHEMBL29772835 | 0.87 | JAK2 (0.57) | JAK1TYK2JAK2JAK3 | |
| SCHEMBL24615462 | 0.87 | JAK2 (0.57) | JAK1TYK2JAK2JAK3 | |
| SCHEMBL24615463 | 0.83 | JAK1 (0.55) | JAK1TYK2JAK2JAK3 | |
| SCHEMBL24615537 | 0.82 | KIT (0.45) | JAK1TYK2JAK2 | |
| SCHEMBL29772852 | 0.82 | KIT (0.45) | JAK1TYK2JAK2 | |
| SCHEMBL29772716 | 0.79 | TYK2 (0.59) | JAK1TYK2JAK2JAK3 | |
| SCHEMBL24615449 | 0.79 | TYK2 (0.59) | JAK1TYK2JAK2JAK3 | |
| SCHEMBL24615445 | 0.78 | JAK1 (0.60) | JAK1TYK2JAK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022150446-A1 | TYK2 INHIBITORS | BIOGEN MA INC. (US) | 2022-07-14 | — | — | WO | disclosed |