Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.66 |
| ▸ | LMNA | P02545 | 5/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | SCN4A | P35499 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 3/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | ILK | Q13418 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20315206 | 0.81 | HTT (0.42) | SMN1; SMN2LMNAMEN1KMT2AMAPT | |
| SCHEMBL23512523 | 0.80 | SMN1; SMN2 (0.41) | SMN1; SMN2LMNAPDE10AALDH1A1HTT | |
| SCHEMBL6664363 | 0.80 | SMN1; SMN2 (1.00) | SMN1; SMN2LMNAKDM4EMEN1KMT2A | |
| SCHEMBL27051812 | 0.78 | SMN1; SMN2 (0.49) | SMN1; SMN2LMNAPDE10AALDH1A1HTT | |
| SCHEMBL101871 | 0.77 | SMN1; SMN2 (0.72) | SMN1; SMN2LMNAKDM4EMEN1KMT2A | |
| SCHEMBL27051825 | 0.75 | SMN1; SMN2 (0.53) | SMN1; SMN2LMNAKDM4EMEN1KMT2A | |
| SCHEMBL24785703 | 0.75 | HTT (0.46) | SMN1; SMN2LMNAMEN1KMT2AMAPT | |
| SCHEMBL27051957 | 0.74 | SMN1; SMN2 (0.49) | SMN1; SMN2LMNAPDE10AALDH1A1HTT | |
| SCHEMBL25167805 | 0.74 | SMN1; SMN2 (0.72) | SMN1; SMN2LMNAKDM4EMEN1KMT2A | |
| SCHEMBL21591736 | 0.74 | SMN1; SMN2 (0.72) | SMN1; SMN2LMNAKDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022148422-A1 | BRIDGED COMPOUNDS AS KRAS G12D INHIBITOR AND DEGRADER AND THE USE THEREOF | BEIGENE, LTD. (KY) | 2022-07-14 | — | — | WO | disclosed |