Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRK2 | P25098 | 2/20 | 0.37 |
| ▸ | GCK | P35557 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | RAF1 | P04049 | 8/20 | 0.34 |
| ▸ | BRAF | P15056 | 8/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 2/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | USP5 | P45974 | 1/20 | 0.31 |
| ▸ | TAF1 | P21675 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29779119 | 1.00 | GRK2 (0.37) | GRK2GCKTSHRRAF1BRAF | |
| SCHEMBL24617003 | 0.87 | GCK (0.38) | GRK2GCKTSHRRAF1BRAF | |
| SCHEMBL24617475 | 0.87 | GCK (0.38) | GRK2GCKTSHRRAF1BRAF | |
| SCHEMBL29778540 | 0.82 | TSHR (0.36) | GRK2GCKTSHRRAF1BRAF | |
| SCHEMBL29778680 | 0.82 | GRK2 (0.40) | GRK2GCKTSHRROCK2BRD4 | |
| SCHEMBL29135988 | 0.82 | GRK2 (0.40) | GRK2GCKTSHRRAF1BRAF | |
| SCHEMBL24617552 | 0.82 | GRK2 (0.40) | GRK2GCKTSHRROCK2BRD4 | |
| SCHEMBL24617551 | 0.82 | GRK2 (0.40) | GRK2GCKTSHRRAF1BRAF | |
| SCHEMBL29135969 | 0.82 | GRK2 (0.40) | GRK2GCKTSHRROCK2BRD4 | |
| SCHEMBL29778910 | 0.82 | GRK2 (0.40) | GRK2GCKTSHRRAF1BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117136186-A | Selective inhibitors of ROCK1 and ROCK2 protein kinases and uses thereof | 盖诺斯克公司 | 2023-11-28 | — | — | CN | claimed |
| CN-117136186-A | Selective inhibitors of ROCK1 and ROCK2 protein kinases and uses thereof | 盖诺斯克公司 | 2023-11-28 | — | — | CN | disclosed |
| WO-2022150381-A1 | SELECTIVE INHIBITORS OF ROCK1 AND ROCK2 PROTEIN KINASES AND USES THEREOF | Genosco Inc. (US) | 2022-07-14 | — | — | WO | disclosed |