Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 8/20 | 0.52 |
| ▸ | MAP4K1 | Q92918 | 4/20 | 0.52 |
| ▸ | BTK | Q06187 | 1/20 | 0.50 |
| ▸ | INSR | P06213 | 3/20 | 0.49 |
| ▸ | EGFR | P00533 | 3/20 | 0.47 |
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24620306 | 1.00 | ALK (0.52) | ALKMAP4K1BTKINSREGFR | |
| SCHEMBL24620221 | 0.97 | MAP4K1 (0.53) | ALKMAP4K1BTKINSREGFR | |
| SCHEMBL24620356 | 0.90 | ALK (0.56) | ALKMAP4K1BTKINSREGFR | |
| SCHEMBL30833037 | 0.90 | ALK (0.56) | ALKMAP4K1BTKINSREGFR | |
| SCHEMBL30833023 | 0.90 | ALK (0.54) | ALKMAP4K1BTKINSR | |
| SCHEMBL24620224 | 0.90 | ALK (0.54) | ALKMAP4K1BTKINSR | |
| SCHEMBL24620193 | 0.88 | MAP4K1 (0.56) | ALKMAP4K1INSRLRRK2 | |
| SCHEMBL24620289 | 0.88 | ALK (0.67) | ALKMAP4K1BTKINSR | |
| SCHEMBL24620328 | 0.88 | ALK (0.67) | ALKMAP4K1BTKINSR | |
| SCHEMBL29791399 | 0.88 | ALK (0.67) | ALKMAP4K1BTKINSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022147622-A1 | ISOINDOLINONE AMINOPYRIMIDINE COMPOUNDS AS INHIBITORS OF NUAK KINASES, COMPOSITIONS AND USES THEREOF | ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR) (CA) | 2022-07-14 | — | — | WO | disclosed |