Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 2/20 | 0.44 |
| ▸ | EGFR | P00533 | 4/20 | 0.43 |
| ▸ | ALK | Q9UM73 | 15/20 | 0.42 |
| ▸ | INSR | P06213 | 4/20 | 0.42 |
| ▸ | IGF1R | P08069 | 3/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.41 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.41 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.41 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.41 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.41 |
| ▸ | PLK4 | O00444 | 1/20 | 0.41 |
| ▸ | STK25 | O00506 | 1/20 | 0.41 |
| ▸ | RIOK3 | O14730 | 1/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
| ▸ | CASK | O14936 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | GAK | O14976 | 1/20 | 0.41 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.41 |
| ▸ | MUSK | O15146 | 1/20 | 0.41 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24620386 | 0.93 | PLK1 (0.43) | PLK1EGFRALKINSRIGF1R | |
| SCHEMBL24620371 | 0.93 | EGFR (0.45) | PLK1EGFRALKINSRIGF1R | |
| SCHEMBL24620237 | 0.89 | ALK (0.54) | PLK1EGFRALKINSRIGF1R | |
| SCHEMBL29791543 | 0.89 | ALK (0.54) | PLK1EGFRALKINSRIGF1R | |
| SCHEMBL24620620 | 0.86 | ALK (0.57) | PLK1EGFRALKINSRIGF1R | |
| SCHEMBL24620277 | 0.86 | PTK2 (0.44) | PLK1EGFRALKINSRIGF1R | |
| SCHEMBL24620633 | 0.83 | ALK (0.56) | PLK1EGFRALKINSRIGF1R | |
| SCHEMBL30833015 | 0.83 | ALK (0.56) | PLK1EGFRALKINSRIGF1R | |
| SCHEMBL24620572 | 0.82 | ALK (0.54) | PLK1EGFRALKINSRIGF1R | |
| SCHEMBL29791402 | 0.82 | ALK (0.54) | PLK1EGFRALKINSRIGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022147622-A1 | ISOINDOLINONE AMINOPYRIMIDINE COMPOUNDS AS INHIBITORS OF NUAK KINASES, COMPOSITIONS AND USES THEREOF | ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR) (CA) | 2022-07-14 | — | — | WO | disclosed |