Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 12/20 | 0.55 |
| ▸ | EGFR | P00533 | 5/20 | 0.53 |
| ▸ | PLK1 | P53350 | 1/20 | 0.49 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.48 |
| ▸ | ULK1 | O75385 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29791454 | 1.00 | ALK (0.55) | ALKEGFRPLK1MAPK3ULK1 | |
| SCHEMBL24620633 | 0.94 | ALK (0.56) | ALKEGFRPLK1MAPK3ULK1 | |
| SCHEMBL30833015 | 0.94 | ALK (0.56) | ALKEGFRPLK1MAPK3ULK1 | |
| SCHEMBL30833050 | 0.93 | ALK (0.61) | ALKEGFRMAPK3ULK1 | |
| SCHEMBL24620370 | 0.93 | ALK (0.61) | ALKEGFRMAPK3ULK1 | |
| SCHEMBL24620237 | 0.92 | ALK (0.54) | ALKEGFRPLK1MAPK3ULK1 | |
| SCHEMBL29791375 | 0.92 | ALK (0.54) | ALKEGFRPLK1MAPK3ULK1 | |
| SCHEMBL29791543 | 0.92 | ALK (0.54) | ALKEGFRPLK1MAPK3ULK1 | |
| SCHEMBL27175302 | 0.92 | ALK (0.54) | ALKEGFRPLK1MAPK3ULK1 | |
| SCHEMBL24620280 | 0.92 | EGFR (0.60) | ALKEGFRPLK1MAPK3ULK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022147622-A1 | ISOINDOLINONE AMINOPYRIMIDINE COMPOUNDS AS INHIBITORS OF NUAK KINASES, COMPOSITIONS AND USES THEREOF | ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR) (CA) | 2022-07-14 | — | — | WO | disclosed |