SCHEMBL24625481

COC(=O)C[C@H]1[C@]2(C)C3=C(C)[C@H](c4ccc(C(C)(C)C)cc4)C[C@H]3O[C@@H]2[C@@H]2OC(=O)[C@]3(C)C=CC(=O)[C@@]1(C)[C@@H]23

nearest known ligand 0.78

Predicted protein targets (top 3)

	gene	UniProt	supporting neighbours	confidence
▸	RNF114	Q9Y508	3/20	0.78

▸	BRD4	O60885	1/20	0.46

▸	HSP90AA1	P07900	1/20	0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL24625130	0.92	RNF114 (0.82)	RNF114BRD4HSP90AA1
SCHEMBL24625482	0.89	RNF114 (0.73)	RNF114BRD4HSP90AA1
SCHEMBL24625292	0.89	RNF114 (0.73)	RNF114BRD4HSP90AA1
SCHEMBL24625094	0.89	RNF114 (0.73)	RNF114BRD4HSP90AA1
SCHEMBL24625091	0.89	RNF114 (0.73)	RNF114BRD4HSP90AA1
Nimbolide SCHEMBL23483973	0.88	RNF114 (1.00)	RNF114BRD4HSP90AA1
Nimbolide SCHEMBL26690496	0.88	RNF114 (1.00)	RNF114BRD4HSP90AA1
Nimbolide SCHEMBL26312156	0.88	RNF114 (1.00)	RNF114BRD4HSP90AA1
Nimbolide SCHEMBL21163877	0.88	RNF114 (1.00)	RNF114BRD4HSP90AA1
SCHEMBL25690951	0.87	RNF114 (0.72)	RNF114BRD4HSP90AA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2022150667-A1	NIMBOLIDE ANALOGS AND METHODS OF USE THEREOF	THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US)	2022-07-14	—	—	WO	disclosed