⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2468573 | 0.72 | — | — | |
| SCHEMBL30848836 | 0.72 | — | — | |
| SCHEMBL7773809 | 0.72 | — | — | |
| SCHEMBL1407387 | 0.67 | — | — | |
| SCHEMBL12226 | 0.67 | — | — | |
| SCHEMBL8052611 | 0.67 | — | — | |
| SCHEMBL1407388 | 0.67 | — | — | |
| SCHEMBL1206368 | 0.65 | — | — | |
| Methylamine SCHEMBL1224408 | 0.65 | — | — | |
| Hydrazine SCHEMBL28757797 | 0.65 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 74 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1307449-B1 | 1,4-DIHYDROPYRIDINES AS BRADYKININ ANTAGONISTS | PFIZER PHARMA (JP) | 2005-12-07 | — | — | EP | claimed |
| US-6653313-B2 | For treatment and prevention of inflammation, asthma, allergic rhinitis, pain and other disorders | WARNER-LAMBERT COMPANY LLC | 2003-11-25 | — | — | US | claimed |
| EP-1307449-A1 | 1,4-DIHYDROPYRIDINES AS BRADYKININ ANTAGONISTS | PFIZER PHARMACEUTICALS INC. (JP) | 2003-05-07 | — | — | EP | claimed |
| US-20020161006-A1 | 1,4-dihydropyridine compounds as bradykinin antagonists | KAWAMURA MITSUHIRO (US) | 2002-10-31 | — | — | US | claimed |
| WO-2002012235-A1 | 1,4-DIHYDROPYRIDINES AS BRADYKININ ANTAGONISTS | PFIZER PHARMACEUTICALS INC. (JP) | 2002-02-14 | — | — | WO | claimed |
| US-5606066-A | Light activable \"caged\" 1-(2-nitrobenzyl)-substituted 1,4-dihydropyridines | GOLDMANN SIEGFRIED (DE) | 1997-02-25 | — | — | US | claimed |
| EP-0533504-B1 | Dihydropyridine derivatives useful in antitumor therapy | PHARMACIA & UPJOHN SPA (IT) | 1997-02-05 | — | — | EP | claimed |
| EP-0533504-A1 | Dihydropyridine derivatives useful in antitumor therapy | PHARMACIA S.p.A. (IT) | 1993-03-24 | — | — | EP | claimed |
| JP-7126251-A | — | — | None | — | — | JP | disclosed |
| US-12012466-B2 | Peptide macrocycles against Acinetobacter baumannii | HOFFMANN-LA ROCHE INC. (US) | 2024-06-18 | — | — | US | disclosed |
| US-20240101590-A1 | METHOD FOR THE SITE-SPECIFIC ENZYMATIC LABELLING OF NUCLEIC ACIDS IN VITRO BY INCORPORATION OF UNNATURAL NUCLEOTIDES | THE SCRIPPS RESEARCH INSTITUTE | 2024-03-28 | — | — | US | disclosed |
| US-11634451-B2 | Method for the site-specific enzymatic labelling of nucleic acids in vitro by incorporation of unnatural nucleotides | THE SCRIPPS RESEARCH INSTITUTE (US) | 2023-04-25 | — | — | US | disclosed |
| US-20220411468-A1 | PEPTIDE MACROCYCLES AGAINST ACINETOBACTER BAUMANNII | HOFFMANN-LA ROCHE INC. (US) | 2022-12-29 | — | — | US | disclosed |
| CN-108350028-B | Peptide macrocycles against Acinetobacter baumannii | 豪夫迈·罗氏有限公司 | 2021-12-07 | — | — | CN | disclosed |
| EP-0533504-A1 | Dihydropyridine derivatives useful in antitumor therapy | PHARMACIA S.p.A. (IT) | 1993-03-24 | — | — | EP | disclosed |
| US-4918074-A | CALCIUM ANTAGONISTS | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1990-04-17 | — | — | US | disclosed |
| US-4751228-A | 1,6-naphthyridine derivatives | GOEDECKE AKTIENGESELLSCHAFT (DE) | 1988-06-14 | — | — | US | disclosed |
| CN-87106032-A | Dihydropyridine anti-allergic agent and anti-inflammatory agent | — | 1988-03-23 | — | — | CN | disclosed |
| CN-86108499-A | 1 of novel fluorine, 4-dihydropyridine compounds and their preparation method and as the purposes of medicine | — | 1987-07-15 | — | — | CN | disclosed |
| EP-0217142-A2 | A polyazaheterocyclic compound | Yoshitomi Pharmaceutical Industries, Ltd. (JP) | 1987-04-08 | — | — | EP | disclosed |